Description

2-[2-[2-(2-Mercaptoethoxy)Ethoxy]Ethoxy]Acetic Acid is a multifunctional organic compound featuring a terminal thiol (mercapto) group and a carboxylic acid group, connected by a flexible polyether chain. This unique structure makes it a valuable heterobifunctional linker and building block for creating custom molecules with specific spacing and reactivity. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors who require precise molecular assembly and surface functionalization.

Application

• Bioconjugation and Protein Modification: The thiol group selectively reacts with maleimides or haloacetyl groups, while the carboxylic acid can be activated for coupling to amines, enabling site-specific labeling of proteins and antibodies.
• Polymer and Dendrimer Synthesis: Serves as a versatile monomer or chain extender for creating functionalized polymers with tailored properties for drug delivery or specialty coatings.
• Surface Functionalization: Used to create self-assembled monolayers (SAMs) on gold or other metal surfaces via the thiol group, introducing carboxylic acid functionalities for subsequent immobilization of biomolecules or catalysts.
• Crosslinking Agent: Acts as a spacer in the formation of hydrogels or polymer networks, where its dual reactivity can be used to control mesh size and mechanical properties.
• Chelating Ligand Synthesis: The polyether backbone and terminal acid group can be modified to synthesize novel ligands for metal ion complexation in catalysis or imaging applications.
• Intermediate for Peptide Mimetics: The structure can be incorporated into peptide chains to introduce specific conformational flexibility or reactive handles.

Basic Information

Product Name	2-[2-[2-(2-Mercaptoethoxy)Ethoxy]Ethoxy]Acetic Acid
CAS No.	200291-35-6
Molecular Formula	C10H20O6S
Molecular Weight	268.33 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecane-14-thioic acid, 14-carboxy-3,6,9-trioxa-12-thiatetradecanoic acid, 3,6,9-Trioxa-12-thiatetradecanoic acid, 14-carboxy-, HS-PEG3-COOH, Thiol-PEG3-acid, 2-[2-[2-(2-Sulfanylethoxy)ethoxy]ethoxy]acetic acid, Mercapto-PEG3-acetic acid
EINECS	Contact for details

Quality Control

Our 2-[2-[2-(2-Mercaptoethoxy)Ethoxy]Ethoxy]Acetic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and moisture absorption. Allow the container to reach room temperature before opening to prevent condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.