Description

4,4',4''-Trifluorotrityl Bromide is a specialized brominated trityl derivative, distinguished by the strategic incorporation of fluorine atoms on its aromatic rings. This compound serves as a crucial protecting group reagent and a versatile building block in advanced organic synthesis, enabling precise molecular construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex active ingredients and fine chemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a robust protecting group for amino acids, particularly for the side-chain protection of lysine and other amines, offering orthogonal deprotection strategies.
• Oligonucleotide Synthesis: Employed in the preparation of nucleoside phosphoramidites, where its stability under acidic conditions is advantageous.
• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of drug candidates, especially those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Development: Used to construct fluorinated scaffolds present in modern herbicides, fungicides, and insecticides.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of novel fluorinated polymers and advanced organic materials.
• Chemical Biology Probes: Facilitates the site-specific labeling and modification of biomolecules for diagnostic and research applications.

Basic Information

Product Name	4,4',4''-Trifluorotrityl Bromide
CAS No.	200004-38-2
Molecular Formula	C21H12BrF3
Molecular Weight	401.22 g/mol
Synonyms	Trityl Bromide, 4,4',4''-Trifluoro-; 4,4',4''-Trifluorotriphenylmethyl Bromide; Tris(4-fluorophenyl)methyl Bromide; (4,4',4''-Trifluorotrityl)bromide; α-Bromo-4,4',4''-trifluorotoluene; 4,4',4''-Trifluoro-α-bromotoluene; TFT-Br; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4,4',4''-Trifluorotrityl Bromide is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.