Description

Bis(Trimethylsilyl)Bromomethane is a versatile organosilicon reagent featuring a reactive bromomethyl group flanked by two trimethylsilyl (TMS) protecting groups. This compound is valued for its dual functionality, serving as a key synthon for the introduction of one-carbon units and as a precursor to reactive intermediates like silyl-substituted carbenes or ylides. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and advanced materials sectors. Its unique structure enables precise synthetic transformations that are difficult to achieve with simpler bromomethylating agents.

Application

• Pharmaceutical Intermediate Synthesis: A crucial building block for constructing complex molecular scaffolds, particularly in the synthesis of novel active pharmaceutical ingredients (APIs).
• Organometallic & Polymer Chemistry: Used as a monomer or functionalizing agent in the development of specialty polymers and organometallic catalysts.
• Agrochemical Research: Employed in the synthesis of experimental herbicides, fungicides, and plant growth regulators requiring specific silicon-containing motifs.
• Material Science Precursor: Acts as a precursor for generating surface-modified nanoparticles or for depositing silicon-containing thin films.
• Cross-Coupling Reactions: Serves as an electrophilic partner in various palladium- or nickel-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Protecting Group Strategy: The TMS groups can be selectively manipulated, making this reagent useful in multi-step synthetic sequences requiring orthogonal protection.

Basic Information

Product Name	Bis(Trimethylsilyl)Bromomethane
CAS No.	29955-12-2
Molecular Formula	C7H19BrSi2
Molecular Weight	239.30 g/mol
Synonyms	Bromobis(trimethylsilyl)methane; (Bromomethyl)bis(trimethylsilyl)methane; 1-Bromo-1,1-bis(trimethylsilyl)methane; Bromomethylenebis(trimethylsilane); TMS2CHBr
EINECS	Contact for details

Quality Control

Every batch of Bis(Trimethylsilyl)Bromomethane is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical research and development. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality systems are designed to support applications requiring high-purity intermediates, including those under cGMP guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.