Description

Chloro(tert-Butyl)Phenylphosphine is a versatile organophosphorus compound widely used as a key ligand and reagent in advanced chemical synthesis. Its primary value lies in its ability to facilitate challenging cross-coupling reactions and serve as a precursor for more complex phosphine ligands, enabling the development of novel materials and pharmaceuticals. This high-purity chemical is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-performance building blocks for catalysis and molecular construction.

Application

• Pharmaceutical Intermediate Synthesis: Acts as a crucial ligand precursor in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Negishi) for constructing complex drug molecules and active pharmaceutical ingredients (APIs).
• Catalyst Development: Serves as a building block for synthesizing specialized, sterically demanding phosphine ligands used in homogeneous catalysis for fine chemical production.
• Agrochemical Research: Employed in the development of novel pesticides and herbicides where phosphorus-containing intermediates are required for structure-activity relationship (SAR) studies.
• Materials Science: Used in the synthesis of phosphine-containing polymers, ligands for quantum dot surface passivation, and precursors for metal-organic frameworks (MOFs).
• Organic Synthesis Reagent: Functions as a reactive intermediate in the preparation of various tertiary phosphines and phosphonium salts for use in Wittig reactions and other methodologies.

Basic Information

Product Name	Chloro(tert-Butyl)Phenylphosphine
CAS No.	29949-69-7
Molecular Formula	C10H14ClP
Molecular Weight	200.64 g/mol
Synonyms	tert-Butyl(chloro)phenylphosphine; (tert-Butyl)chlorophenylphosphine; Chloro(tert-butyl)phenylphosphane; P-Chloro-P-(tert-butyl)-P-phenylphosphine; Phenyl-tert-butyl-chlorophosphine; t-BuPhPCl; tert-Butylphenylphosphinous Chloride
EINECS	Contact for details

Quality Control

Our Chloro(tert-Butyl)Phenylphosphine is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ³¹P), GC, and HPLC analysis, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This material is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
³¹P NMR Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.