Description

Dl-Leucine-D10 is a stable isotope-labeled analog of the essential amino acid leucine, where ten hydrogen atoms are replaced by deuterium. This deuteration is critical for applications requiring precise molecular tracking and quantification, as it provides a distinct mass signature without altering the fundamental chemical behavior. It is an indispensable tool for researchers and manufacturers in the pharmaceutical and life sciences sectors who require high-fidelity internal standards for mass spectrometry, metabolic pathway studies, and drug development.

Application

• Mass Spectrometry Internal Standard: Serves as a critical quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of endogenous leucine levels in biological samples.
• Metabolic Research: Used as a tracer in kinetic studies and metabolic flux analysis to investigate protein synthesis, turnover, and amino acid metabolism pathways.
• Pharmaceutical Development: Employed in the research and quality control of deuterated drug candidates, aiding in pharmacokinetic and bioavailability studies.
• Nutritional Science: Applied in stable isotope probing to study amino acid utilization, requirements, and the impact of dietary interventions.
• Biochemical Assays: Utilized in enzymatic assays and receptor binding studies where a non-radioactive, isotopically labeled substrate is required.
• Proteomics & Biomarker Discovery: Facilitates relative and absolute quantification (AQUA) of proteins and peptides in complex mixtures.

Basic Information

Product Name	Dl-Leucine-D10
CAS No.	29909-01-1
Molecular Formula	C6D10H3NO2
Molecular Weight	137.20 g/mol (for deuterated form)
Synonyms	DL-Leucine-d10; (RS)-Leucine-d10; (±)-2-Amino-4-methylpentanoic-3,3,4,4,5,5,5-d7,2-d3 acid; 2-Amino-4-methylpentanoic-3,3,4,4,5,5,5-d7,2-d3 acid; Leucine-d10 (racemic); Deuterated DL-Leucine; Amino acid-d10 internal standard
EINECS	Contact for details

Quality Control

Every batch of Dl-Leucine-D10 is manufactured and tested under strict quality management protocols to ensure exceptional isotopic purity and chemical integrity, meeting the exacting requirements of analytical and research applications. Our standard specifications focus on isotopic enrichment (atom % D), chemical purity, and the absence of interfering impurities. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and identity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.