Description

(Z)-3-(Dimethoxyphosphinyloxy)-2-Butenoic Acid 1-Phenylethyl Ester is a specialized organophosphorus compound that serves as a critical chiral intermediate in advanced synthetic chemistry. Its value lies in its unique structure, which is designed for the stereoselective construction of complex molecules, particularly in the synthesis of biologically active compounds. This high-purity intermediate is essential for research and development laboratories and production facilities in the pharmaceutical and agrochemical industries, where precise control over molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring specific stereochemistry.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the (Z)-configuration and phosphonate moiety are crucial for biological activity.
• Asymmetric Synthesis: Employed in stereoselective reactions, such as Horner-Wadsworth-Emmons (HWE) olefinations, to create defined double bonds in complex natural products and fine chemicals.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on developing new synthetic methodologies and exploring structure-activity relationships.
• Ligand and Catalyst Precursor: Serves as a starting material for the synthesis of specialized phosphonate-based ligands used in catalytic systems.

Basic Information

Product Name	(Z)-3-(Dimethoxyphosphinyloxy)-2-Butenoic Acid 1-Phenylethyl Ester
CAS No.	29900-31-0
Molecular Formula	C14H19O6P
Molecular Weight	314.27 g/mol
Synonyms	(Z)-1-Phenylethyl 3-(dimethoxyphosphoryloxy)but-2-enoate; (Z)-α-Methylbenzyl 3-(dimethoxyphosphoryloxy)crotonate; (Z)-3-(Dimethoxyphosphoryloxy)-2-butenoic Acid 1-Phenylethyl Ester; (Z)-Phosphonoacetic Acid, 3-Oxo-, 1-Phenylethyl Ester, Dimethyl Ester; (Z)-Dimethyl (1-Phenylethoxycarbonylvinyl)phosphate; (Z)-HWE Reagent, 1-Phenylethyl Ester; (Z)-Horner-Wadsworth-Emmons Reagent
EINECS	Contact for details

Quality Control

Our production of (Z)-3-(Dimethoxyphosphinyloxy)-2-Butenoic Acid 1-Phenylethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC to confirm identity, isomeric purity ((Z)-configuration), and chemical assay. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity ((Z)-isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.