Description

3,5-Bis(1,1-Dimethylethyl)Phenyl (1,1-Dimethylethyl)Phosphinyl Chloride is a specialized organophosphorus compound, CAS 29634-14-8, that serves as a critical building block in advanced organic synthesis. Its value lies in its role as a reactive intermediate for introducing sterically hindered phosphinate and phosphine oxide functional groups into complex molecular architectures. This high-purity reagent is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as for creating specialized ligands for catalysis and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly those requiring sterically hindered phosphinate ester or phosphine oxide moieties for enhanced bioactivity or stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where the bulky tert-butylphenyl groups impart favorable properties like selectivity and environmental persistence.
• Ligand Precursor for Catalysis: Serves as a starting material for synthesizing sophisticated phosphine-based ligands used in asymmetric catalysis and cross-coupling reactions (e.g., Suzuki, Heck).
• Polymer Modification: Employed to introduce phosphinate groups into polymer backbones or side chains, enhancing flame retardancy, adhesion, or thermal stability of high-performance materials.
• Coordination Chemistry & Material Science: Useful for creating metal-organic frameworks (MOFs) or functional surfaces with tailored phosphinate ligands for sensing, separation, or catalysis applications.
• Organic Synthesis Reagent: A versatile reagent for constructing complex organic molecules, enabling P-C and P-O bond formation under controlled conditions.

Basic Information

Product Name	3,5-Bis(1,1-Dimethylethyl)Phenyl (1,1-Dimethylethyl)Phosphinyl Chloride
CAS No.	29634-14-8
Molecular Formula	C18H30ClOP
Molecular Weight	328.86 g/mol
Synonyms	(3,5-Di-tert-butylphenyl)(tert-butyl)phosphinic chloride; tert-Butyl(3,5-di-tert-butylphenyl)phosphinic chloride; Phosphinic chloride, (1,1-dimethylethyl)[3,5-bis(1,1-dimethylethyl)phenyl]-; (3,5-Di-tert-butylphenyl)(tert-butyl)phosphinyl chloride; tert-Butylphosphinic chloride, 3,5-di-tert-butylphenyl ester; P-Chloro-P-(3,5-di-tert-butylphenyl)-P-tert-butylphosphine oxide
EINECS	Contact for details

Quality Control

Our production of 3,5-Bis(1,1-Dimethylethyl)Phenyl (1,1-Dimethylethyl)Phosphinyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are subjected to rigorous analytical testing, including NMR, HPLC, and titration methods. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Chloride Content (Titration)	10.5 - 11.2 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.