Description

Phenylthiohydantoin Phenylalanine is a specialized derivative of phenylalanine, a crucial amino acid, where the phenylthiohydantoin (PTH) group is attached. This compound is of significant value in analytical biochemistry and peptide research, serving as a key intermediate or standard. It is primarily required by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in advanced protein sequencing, peptide synthesis, and analytical method development.

Application

• Edman Degradation Reagent: Used as a critical derivative for the identification of phenylalanine residues during stepwise peptide sequencing.
• Analytical Reference Standard: Employed in High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) for the calibration and validation of protein/peptide analysis systems.
• Biochemical Research: Serves as a building block or intermediate in the study of amino acid metabolism and the synthesis of modified peptides.
• Pharmaceutical Development: Utilized in the research and quality control stages of peptide-based drug development.
• Proteomics: Acts as a specific marker or tool in the detailed mapping and characterization of complex protein mixtures.

Basic Information

Product Name	Phenylthiohydantoin Phenylalanine
CAS No.	29588-07-6
Molecular Formula	C₁₆H₁₄N₂O₂S
Molecular Weight	298.36 g/mol
Synonyms	PTH-Phenylalanine; 3-Phenyl-2-thiohydantoin-5-ylalanine; Phenylalanine Phenylthiohydantoin; 5-(1-Carboxy-2-phenylethyl)-2-thiohydantoin; Edman Degradation Product of Phenylalanine; PTH-Phe; (RS)-5-(1-Carboxy-2-phenylethyl)-2-thioxoimidazolidin-4-one
EINECS	Contact for details

Quality Control

Our Phenylthiohydantoin Phenylalanine is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.