Description

5-Cyclopropyl-2-Thiophenecarboxaldehyde is a versatile heterocyclic building block featuring a reactive aldehyde group on a thiophene scaffold substituted with a cyclopropyl moiety. This compound matters as a critical intermediate for synthesizing complex molecules, enabling the introduction of both thiophene and cyclopropyl pharmacophores into target structures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the bioactivity of the thiophene and cyclopropyl groups.
• Material Science Research: Serves as a precursor for organic semiconductors, conductive polymers, and liquid crystals due to the electron-rich thiophene core.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for metal-catalyzed cross-coupling reactions and other catalytic processes.
• Chemical Biology Probes: Utilized to create molecular probes and fluorescent tags for studying biological systems and mechanisms.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for fine chemical manufacturers offering bespoke synthesis services to clients.

Basic Information

Product Name	5-Cyclopropyl-2-Thiophenecarboxaldehyde
CAS No.	29481-26-3
Molecular Formula	C8H8OS
Molecular Weight	152.21 g/mol
Synonyms	5-Cyclopropylthiophene-2-carboxaldehyde; 2-Formyl-5-cyclopropylthiophene; 5-Cyclopropyl-2-thiophenecarbaldehyde; 5-Cyclopropylthiophene-2-carbaldehyde; Cyclopropylthiophenecarboxaldehyde; (5-Cyclopropylthiophen-2-yl)methanal; 29481-26-3; 2-Thiophenecarboxaldehyde, 5-cyclopropyl-
EINECS	Contact for details

Quality Control

Our 5-Cyclopropyl-2-Thiophenecarboxaldehyde is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.