Description

1,2-Di[Perdeutero]Hexadecanoyl-Sn-Glycero-3-Phosphocholine is a deuterated phospholipid, specifically a perdeuterated analog of the common lipid DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine). This compound is critically valuable for advanced research applications where isotopic labeling is required to eliminate background signal interference. It is primarily needed by researchers and developers in the fields of structural biology, biophysics, and pharmaceutical sciences for techniques like neutron scattering, NMR spectroscopy, and membrane dynamics studies.

Application

• Neutron Scattering Studies: Used to create deuterated lipid bilayers for investigating membrane structure and protein-lipid interactions with high contrast.
• NMR Spectroscopy: Serves as a critical tool in nuclear magnetic resonance for studying lipid dynamics, domain formation, and molecular interactions within membranes without proton signal interference.
• Model Membrane Systems: A key component in the preparation of stable, defined liposomes and vesicles for drug delivery research and membrane biophysics.
• Biophysical Research: Enables precise measurement of phase transition temperatures, packing density, and fluidity in artificial and complex membrane models.
• Pharmaceutical Development: Utilized in the formulation and study of lipid-based nanoparticle carriers (LNPs) for mRNA and other therapeutic agents.
• Metabolic Tracing: Acts as a stable isotopic tracer in metabolic studies to track phospholipid synthesis and turnover.

Basic Information

Product Name	1,2-Di[Perdeutero]Hexadecanoyl-Sn-Glycero-3-Phosphocholine
CAS No.	29287-66-9
Molecular Formula	C40D78NO8P
Molecular Weight	~790.0 g/mol (Calculated for deuterated form)
Synonyms	Perdeuterated DPPC; d62-DPPC; 1,2-Dipalmitoyl(d62)-sn-glycero-3-phosphocholine; Deuterated DPPC; 1,2-Bis(hexadecanoyl-d31)-sn-glycero-3-phosphocholine; DPPC-d62; [D62]-DPPC; 1,2-Dihexadecanoyl-d62-glycero-3-phosphocholine
EINECS	Contact for details

Quality Control

Our deuterated phospholipids are produced and handled under strict quality protocols to ensure isotopic purity and chemical integrity, which are paramount for sensitive research applications. Each batch is characterized using advanced analytical techniques including NMR and Mass Spectrometry to confirm deuteration level and chemical purity. Certificates of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical purity (by HPLC), and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Isotopic Purity (Deuteration Level)	>98 atom % D (by 2H NMR or MS)
Chemical Purity (HPLC)	>95%
Solubility	Soluble in chloroform, methanol; forms liposomes in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.