Description

1,2,3,4-Tetrahydro-8-Hydroxy-6,7-Dimethoxy-1-Methyl-1-Isoquinolinecarboxylic Acid is a specialized isoquinoline derivative of significant interest in advanced organic synthesis. This compound serves as a key chiral building block and synthetic intermediate for the development of complex pharmaceutical molecules and bioactive alkaloids. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of tetrahydroisoquinoline-based active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and the design of novel therapeutic agents targeting neurological and cardiovascular systems.
• Alkaloid Synthesis: Serves as a key intermediate in the total synthesis of complex natural products and isoquinoline alkaloids.
• Chiral Building Block: Utilized in asymmetric synthesis to introduce the tetrahydroisoquinoline core with defined stereochemistry into target molecules.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for high-value fine chemicals under GMP or non-GMP conditions.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1,2,3,4-Tetrahydro-8-Hydroxy-6,7-Dimethoxy-1-Methyl-1-Isoquinolinecarboxylic Acid
CAS No.	29194-00-1
Molecular Formula	C₁₃H₁₇NO₅
Molecular Weight	267.28 g/mol
Synonyms	8-Hydroxy-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 1-Carboxy-8-hydroxy-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline; THIQ-COOH derivative; (1S)-1,2,3,4-Tetrahydro-8-hydroxy-6,7-dimethoxy-1-methyl-1-isoquinolinecarboxylic acid (if stereospecific); 1-Methyl-1,2,3,4-tetrahydro-8-hydroxy-6,7-dimethoxyisoquinoline-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-8-Hydroxy-6,7-Dimethoxy-1-Methyl-1-Isoquinolinecarboxylic Acid is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral purity analysis, and comprehensive identification, to ensure it meets exacting standards for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting regulatory documentation and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee (if applicable)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.