Description

Secobarbital, 1.0 mg/mL in methanol is a certified reference material (CRM) solution, precisely formulated for analytical and research applications. This product provides a reliable and consistent standard for the accurate quantification and identification of secobarbital, a short-acting barbiturate derivative. It is an essential tool for laboratories in the pharmaceutical, forensic, and clinical toxicology sectors requiring high-purity analytical standards for method validation, quality control, and regulatory compliance.

Application

• Analytical Method Development and Validation: Primary standard for calibrating HPLC, GC-MS, and LC-MS/MS systems in pharmaceutical analysis.
• Forensic Toxicology: Critical reference for the identification and quantification of secobarbital in biological matrices during drug testing and post-mortem investigations.
• Pharmaceutical Quality Control (QC): Used as an external standard to assay the purity and potency of active pharmaceutical ingredients (APIs) and finished drug products containing barbiturates.
• Clinical Research: Supports studies on drug metabolism, pharmacokinetics, and therapeutic drug monitoring (TDM) for barbiturate medications.
• Regulatory Compliance Testing: Essential for laboratories adhering to FDA, EMA, or other global regulatory guidelines that require traceable and certified reference materials.
• Environmental and Doping Control Analysis: Reference standard for detecting secobarbital in specialized screening programs.

Basic Information

Item	Details
Product Name	Secobarbital, 1.0 mg/mL in Methanol
CAS No.	29071-21-4
Molecular Formula	C12H18N2O3
Molecular Weight	238.28 g/mol
Synonyms	Secobarbital; 5-Allyl-5-(1-methylbutyl)barbituric acid; Seconal; Quinalbarbitone; Meballymal; Secobarbital sodium derivative; 5-(1-Methylbutyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
EINECS	Contact for details

Quality Control

Every batch of our Secobarbital CRM solution is manufactured and certified under strict quality management systems. The product is characterized using orthogonal analytical techniques including HPLC-DAD, GC-MS, and NMR to ensure identity, purity, and concentration accuracy. A comprehensive Certificate of Analysis (COA) is provided with each unit, detailing batch-specific results, traceability to NIST standards where applicable, and expiration date. Our quality protocols are designed to meet the needs of GMP/GLP-compliant laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated). The solution is highly volatile due to the methanol solvent and is light-sensitive. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Concentration	1.0 mg/mL ± 5%
Solvent	Methanol (HPLC/GC Grade)
Identification (IR / HPLC Retention Time)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% of declared concentration
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.