Description

2-Chloro-5-Iodothiophene is a halogenated thiophene derivative, a versatile and high-value heterocyclic building block in advanced organic synthesis. Its molecular structure, featuring both chlorine and iodine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, particularly for developing active pharmaceutical ingredients (APIs), functional polymers, and liquid crystal materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the thiophene core contributes to biological activity.
• Organic Electronic Materials: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), field-effect transistors (OFETs), and photovoltaic cells.
• Liquid Crystal & Dye Chemistry: Employed in the synthesis of functional dyes and liquid crystal compounds for display technologies and sensors.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), enabling rapid diversification of molecular structures.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in synthetic methodology and heterocyclic chemistry.

Basic Information

Product Name	2-Chloro-5-Iodothiophene
CAS No.	28712-49-4
Molecular Formula	C4H2ClIS
Molecular Weight	244.48 g/mol
Synonyms	5-Iodo-2-chlorothiophene; 2-Chloro-5-iodothiophene; Thiophene, 2-chloro-5-iodo-; 2-Chloro-5-iodo-thiophene; 2-Chloro-5-iodothiophene; 2-Chloro-5-iodothiophene (28712-49-4); 2-Chloro-5-iodo-1-thiophene; 5-Iodo-2-chloro-thiophene
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Iodothiophene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with your specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.