Description

1-(α,α,α-Trifluoro-m-Toluoyl)-1H-Indazol-5-Amine is a high-purity, specialized indazole derivative featuring a trifluoromethylated benzoyl moiety, making it a valuable synthetic intermediate and building block. This compound is critical for research and development in advanced pharmaceutical and agrochemical synthesis, where its unique fluorine-substituted aromatic structure imparts desirable metabolic stability and bioactivity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in kinase inhibitor and targeted cancer therapy research.
• Agrochemical Research: Used in developing new-generation herbicides and pesticides, leveraging the trifluoromethyl group for enhanced efficacy and environmental profile.
• Chemical Biology Probe: Serves as a core scaffold for designing molecular probes to study enzyme function and biological pathways.
• Material Science Precursor: Potential intermediate for synthesizing specialty polymers and organic electronic materials requiring fluorinated aromatic units.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic projects.

Basic Information

Product Name	1-(α,α,α-Trifluoro-m-Toluoyl)-1H-Indazol-5-Amine
CAS No.	28616-30-0
Molecular Formula	C15H10F3N3O
Molecular Weight	305.26 g/mol
Synonyms	5-Amino-1-[3-(trifluoromethyl)benzoyl]-1H-indazole; 1-[3-(Trifluoromethyl)benzoyl]-1H-indazol-5-amine; 1H-Indazol-5-amine, 1-[3-(trifluoromethyl)benzoyl]-; 1-(3-Trifluoromethylbenzoyl)indazol-5-ylamine; 5-Amino-1-(3-trifluoromethylbenzoyl)indazole; 28616-30-0; α,α,α-Trifluoro-m-toluoyl-1H-indazol-5-amine
EINECS	Contact for details

Quality Control

Every batch of 1-(α,α,α-Trifluoro-m-Toluoyl)-1H-Indazol-5-Amine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.