Description

1,4-Bis-Maleimidobutane is a high-purity, bifunctional cross-linking agent belonging to the maleimide family. This compound is valued for its ability to form stable covalent bonds with thiol groups under mild conditions, making it an essential reagent in advanced material synthesis and bioconjugation. It is primarily utilized by researchers and manufacturers in the pharmaceutical, polymer, and life science industries for applications ranging from hydrogel formation to protein and antibody modification.

Application

• Polymer Cross-Linking Agent: Used in the synthesis of high-performance thermosetting resins, polyimides, and elastomers to enhance thermal stability and mechanical properties.
• Bioconjugation Reagent: Essential for site-specific labeling and modification of proteins, antibodies, and peptides in drug development and diagnostic assay kits.
• Hydrogel Formation: Serves as a key cross-linker in the creation of biocompatible hydrogels for tissue engineering, drug delivery systems, and 3D cell culture scaffolds.
• Surface Functionalization: Used to modify material surfaces (e.g., gold nanoparticles, silicon wafers) to introduce reactive maleimide groups for subsequent coupling.
• Adhesive & Composite Materials: A component in formulations for high-temperature adhesives, coatings, and advanced composite materials requiring robust chemical resistance.
• Research & Development: A critical building block in organic synthesis and materials science R&D for creating novel macromolecular architectures.

Basic Information

Product Name	1,4-Bis-Maleimidobutane
CAS No.	28537-70-4
Molecular Formula	C12H14N2O4
Molecular Weight	250.25 g/mol
Synonyms	1,4-Bismaleimidobutane; 1,1'-(1,4-Butanediyl)bis-1H-pyrrole-2,5-dione; N,N'-1,4-Butanediylbismaleimide; Bismaleimide crosslinker BMI; BMI; 1,4-Bis(maleimido)butane; Tetramethylene bismaleimide; Butane-1,4-diyl bis(2,5-dihydro-2,5-dioxo-1H-pyrrole-1-carboxylate)
EINECS	Contact for details

Quality Control

Our 1,4-Bis-Maleimidobutane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial applications. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	155 - 165 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.