Description

(+)-2,3-Dihydro-6-Methyl-3-Methylenebenzofuran-2-Ol is a chiral benzofuran derivative, a high-value intermediate prized for its defined stereochemistry and reactive methylene group. This compound is critical for synthesizing complex molecules where precise spatial orientation is required for biological activity or material properties. It is primarily sought by the pharmaceutical, agrochemical, and advanced materials research sectors for applications in drug discovery, crop protection, and specialty polymer development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its benzofuran core for bioactive molecule design.
• Organic Synthesis & Catalysis: Acts as a versatile precursor for synthesizing complex natural products and as a ligand in asymmetric catalysis.
• Material Science Research: Investigated as a monomer or functional additive for creating specialized polymers with unique optical or electronic properties.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing specific aroma chemicals due to its benzofuran structure.
• Academic & R&D Laboratories: Employed in methodological studies and as a reference standard in chemical research.

Basic Information

Product Name	(+)-2,3-Dihydro-6-Methyl-3-Methylenebenzofuran-2-Ol
CAS No.	28330-05-4
Molecular Formula	C11H12O2
Molecular Weight	176.21 g/mol
Synonyms	(+)-6-Methyl-3-methylenebenzofuran-2(3H)-one hydrate; (3R)-3-Hydroxy-6-methyl-3-methylidene-2,3-dihydro-1-benzofuran; (R)-3-Hydroxy-6-methyl-3-methylenebenzofuran-2(3H)-one; 6-Methyl-3-methylenebenzofuran-2-ol; (R)-6-Methyl-3-methylenebenzofuran-2-ol; 2(3H)-Benzofuranone, 3-ethenyl-3-hydroxy-6-methyl-, (3R)-; 28330-05-4
EINECS	Contact for details

Quality Control

Our (+)-2,3-Dihydro-6-Methyl-3-Methylenebenzofuran-2-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure high chemical and enantiomeric purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.