Description

(4-Cyano-Phenyl)-Phosphonic Acid Diethyl Ester is a high-purity organophosphorus compound that serves as a critical synthetic intermediate and ligand precursor. Its value lies in the unique reactivity imparted by the combination of a cyano group and a phosphonate ester moiety on a phenyl ring, enabling precise molecular construction. This chemical is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require a reliable building block for creating complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting bone diseases or requiring phosphate bioisosteres.
• Agrochemical Synthesis: Used in the production of novel herbicides, plant growth regulators, and insecticides where the phosphonate group enhances systemic activity.
• Ligand & Catalyst Preparation: Serves as a precursor for phosphonic acid ligands used in metal-organic frameworks (MOFs), homogeneous catalysis, and surface modification.
• Material Science: Employed in the development of flame retardants, corrosion inhibitors, and specialty polymers where phosphorus incorporation improves material performance.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions, such as the Hirao cross-coupling, for forming carbon-phosphorus bonds.
• Chemical Research: A versatile reagent in organic synthesis for introducing functionalized phenylphosphonate groups into target molecules.

Basic Information

Product Name	(4-Cyano-Phenyl)-Phosphonic Acid Diethyl Ester
CAS No.	28255-72-3
Molecular Formula	C11H14NO3P
Molecular Weight	239.21 g/mol
Synonyms	Diethyl (4-Cyanophenyl)phosphonate; Diethyl 4-Cyanobenzylphosphonate; (4-Cyanophenyl)phosphonic Acid Diethyl Ester; p-Cyanophenylphosphonic Acid Diethyl Ester; Diethyl P-Cyanobenzylphosphonate; Phosphonic Acid, P-(4-Cyanophenyl)-, Diethyl Ester; Diethyl (4-Cyanobenzyl)phosphonate; 4-Cyanophenylphosphonic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our (4-Cyano-Phenyl)-Phosphonic Acid Diethyl Ester is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and FTIR to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment ensures the material meets the stringent requirements for research and commercial synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.