Description

2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-6-o-[Bis(Trimethylsiloxy)Phosphinyl]-D-Gluconic Acid Trimethylsilyl Ester is a highly functionalized, fully protected derivative of D-gluconic acid, featuring multiple trimethylsilyl (TMS) groups and a phosphinyl moiety. This compound is a critical advanced synthetic intermediate for the preparation of complex carbohydrates, nucleoside analogs, and other bioactive molecules where precise stereochemistry and protection are paramount. It is essential for researchers and manufacturers in pharmaceutical development, carbohydrate chemistry, and fine chemical synthesis who require high-purity, specialized building blocks.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside-based antiviral or anticancer agents.
• Carbohydrate Chemistry: Serves as a protected precursor for the stereoselective synthesis of complex oligosaccharides and glycoconjugates.
• Chemical Biology Probes: Used in the development of labeled or modified sugars for studying metabolic pathways and enzyme mechanisms.
• Fine Chemical Synthesis: An advanced intermediate for creating chiral ligands, catalysts, or specialty polymers with specific functional groups.
• Glycomics Research: Essential tool for researchers constructing defined glycan structures to study protein-carbohydrate interactions.
• Process Development: Employed in scaling up routes to carbohydrate-derived active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-6-o-[Bis(Trimethylsiloxy)Phosphinyl]-D-Gluconic Acid Trimethylsilyl Ester
CAS No.	28176-77-4
Molecular Formula	C27H67NO11PSi7
Molecular Weight	852.48 g/mol
Synonyms	D-Gluconic acid, 2,3,4,5-tetrakis-O-(trimethylsilyl)-6-O-[bis(trimethylsiloxy)phosphinyl]-, trimethylsilyl ester; Fully TMS-protected D-gluconic acid phosphonate ester; 6-O-[Bis(trimethylsiloxy)phosphinyl]-2,3,4,5-tetrakis-O-(trimethylsilyl)-D-gluconic acid trimethylsilyl ester; Gluconic acid, per-TMS, 6-phosphinyl derivative; TMS-Gluconic Acid Phosphonate Ester
EINECS	Contact for details

Quality Control

Every batch of this specialty intermediate is produced and analyzed under strict quality protocols to ensure high chemical purity and structural integrity, critical for sensitive synthetic applications. Our quality system employs advanced analytical techniques including NMR, HPLC, and MS for definitive characterization. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening. Handle and store away from strong bases and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.