Description

α-Cyano-4-Hydroxycinnamic Acid is a high-purity, crystalline organic acid derivative widely recognized as a critical matrix material for Matrix-Assisted Laser Desorption/Ionization (MALDI) mass spectrometry. Its primary value lies in its exceptional ability to facilitate the soft ionization of a broad range of analytes, including peptides, proteins, and polymers, enabling precise molecular weight determination. This compound is essential for research and quality control laboratories in the pharmaceutical, proteomics, and biotech industries, where accurate mass analysis is paramount for drug discovery, biomarker identification, and material characterization.

Application

• MALDI-TOF Mass Spectrometry Matrix: The predominant application, serving as an efficient energy-absorbing matrix for the analysis of proteins, peptides, oligonucleotides, and synthetic polymers.
• Proteomics and Biomarker Research: Enables high-throughput protein profiling, peptide mass fingerprinting, and the discovery of disease biomarkers.
• Pharmaceutical Analysis: Used in drug development for the characterization of APIs (Active Pharmaceutical Ingredients), metabolites, and impurities.
• Polymer Chemistry: Facilitates the analysis of polymer molecular weight distributions and end-group analysis.
• Material Science: Applied in the surface analysis of organic materials and coatings.
• Academic and Industrial R&D: A standard reagent in laboratories focused on analytical chemistry, biochemistry, and life sciences.

Basic Information

Product Name	α-Cyano-4-Hydroxycinnamic Acid
CAS No.	28166-41-8
Molecular Formula	C10H7NO3
Molecular Weight	189.17 g/mol
Synonyms	CHCA; α-Cyano-4-hydroxycinnamic acid; 4-Hydroxy-α-cyanocinnamic acid; 3-(4-Hydroxyphenyl)-2-cyanoacrylic acid; (2E)-2-Cyano-3-(4-hydroxyphenyl)prop-2-enoic acid; MALDI Matrix CHCA; Cinnamic acid, α-cyano-4-hydroxy-; 2-Propenoic acid, 2-cyano-3-(4-hydroxyphenyl)-, (2E)-
EINECS	Contact for details

Quality Control

Our α-Cyano-4-Hydroxycinnamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification, to ensure it meets the high standards required for sensitive analytical applications like MALDI-TOF MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and performance consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture, which can affect performance. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	250 - 255 °C (dec.)
Loss on Drying	≤ 1.0 %
Heavy Metals (as Pb)	≤ 20 ppm
Solubility (Test in ACN)	Clear, colorless solution
UV Absorption	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.