Description

1-Bromo-4-Pentyne is a versatile alkyne-containing alkyl bromide, a key building block in organic synthesis. Its reactive bromine and terminal alkyne functional groups make it an invaluable intermediate for constructing complex molecular architectures through cross-coupling and cycloaddition reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors developing new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a crucial synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in the synthesis of compounds with alkyne-linked side chains or heterocyclic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators, leveraging its ability to introduce propargylic or pentynyl motifs.
• Material Science: Acts as a monomer or cross-linking agent in polymer chemistry for creating specialty polymers, dendrimers, and functionalized surfaces with tailored properties.
• Click Chemistry: An ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling efficient bioconjugation and the synthesis of triazole-based compounds.
• Organic Synthesis Reagent: Employed in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Ligand and Catalyst Development: Used to synthesize novel phosphine or nitrogen-based ligands containing alkyne functionalities for catalytic systems.

Basic Information

Product Name	1-Bromo-4-Pentyne
CAS No.	28077-72-7
Molecular Formula	C5H7Br
Molecular Weight	147.01 g/mol
Synonyms	4-Pentyn-1-yl Bromide; 5-Bromo-1-pentyne; Bromopentyne; 1-Bromo-4-pentyne; 4-Pentynyl Bromide; Pent-4-yn-1-yl Bromide; 5-Bromopentyne
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Pentyne is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.