Description

2-(5-Ethenyl-1-Azabicyclo[2.2.2]Octan-2-Yl)-1,2-Dihydro-2-(2-Hydroxyethyl)-3H-Indol-3-One is a complex heterocyclic compound featuring a quinuclidine core fused with an indolinone moiety, making it a valuable advanced pharmaceutical intermediate. Its intricate molecular architecture is crucial for synthesizing specialized active pharmaceutical ingredients (APIs) with targeted biological activity. This high-purity compound is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in neurological and receptor-targeted drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of complex drug candidates and novel chemical entities (NCEs).
• Neurological Research: Used in the development and study of compounds targeting the central nervous system due to its structural similarity to certain alkaloids and receptor ligands.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for pharmaceutical clients.
• Academic Research: Utilized in university and institutional labs for synthetic organic chemistry studies and the exploration of new heterocyclic reactions.
• Pre-clinical Development: Employed in the synthesis of compounds for pharmacological screening and pre-clinical evaluation.

Basic Information

Product Name	2-(5-Ethenyl-1-Azabicyclo[2.2.2]Octan-2-Yl)-1,2-Dihydro-2-(2-Hydroxyethyl)-3H-Indol-3-One
CAS No.	28047-77-0
Molecular Formula	C19H24N2O2
Molecular Weight	312.41 g/mol
Synonyms	2-(5-Vinyl-1-azabicyclo[2.2.2]octan-2-yl)-1,2-dihydro-2-(2-hydroxyethyl)-3H-indol-3-one; 2-(5-Ethenyl-2-azabicyclo[2.2.2]oct-2-yl)-2-(2-hydroxyethyl)indolin-3-one; 28047-77-0; Quinuclidine-indolinone derivative; 3H-Indol-3-one, 2-(5-ethenyl-1-azabicyclo[2.2.2]oct-2-yl)-1,2-dihydro-2-(2-hydroxyethyl)-; (2-(2-Hydroxyethyl)-2-(5-vinylquinuclidin-2-yl)indolin-3-one)
EINECS	Contact for details

Quality Control

Our 2-(5-Ethenyl-1-Azabicyclo[2.2.2]Octan-2-Yl)-1,2-Dihydro-2-(2-Hydroxyethyl)-3H-Indol-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data and full characterization are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.