Description

4-Benzyl-2-Thiophenecarboxylic Acid is a high-value heterocyclic building block featuring a thiophene core functionalized with both a benzyl and a carboxylic acid group. This compound matters as a versatile intermediate in advanced organic synthesis, enabling the construction of complex molecules for pharmaceutical and material science research. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as drug discovery and the development of novel functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly those containing thiophene or benzyl-thiophene motifs.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the thiophene scaffold imparts specific biological activity.
• Material Science Research: Serves as a precursor for organic semiconductors, conductive polymers, and liquid crystals due to the electron-rich nature of the thiophene ring.
• Ligand and Catalyst Development: The carboxylic acid group allows for functionalization into chelating ligands for metal catalysts used in cross-coupling and other organic transformations.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target identification.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Benzyl-2-Thiophenecarboxylic Acid
CAS No.	27921-49-9
Molecular Formula	C12H10O2S
Molecular Weight	218.27 g/mol
Synonyms	2-Thiophenecarboxylic acid, 4-(phenylmethyl)-; 4-(Phenylmethyl)-2-thiophenecarboxylic acid; 4-Benzylthiophene-2-carboxylic acid; 2-Carboxy-4-benzylthiophene; 4-Benzyl-2-thiophenecarboxylic acid; 4-Benzylthiophene-2-carboxylic acid; 27921-49-9
EINECS	Contact for details

Quality Control

Our 4-Benzyl-2-Thiophenecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.