Description

(S)-1-Amino-2-Hydroxymethylindoline is a chiral indoline derivative of significant importance in modern synthetic organic chemistry. This compound serves as a versatile and high-value building block for the construction of complex, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potent drug candidates, especially those targeting neurological disorders.
• Asymmetric Synthesis: Used as a precursor or ligand in catalytic asymmetric reactions to induce chirality in target molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs due to its rigid indoline scaffold.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and receptor binding.
• Agrochemical Development: Potential intermediate for creating novel chiral pesticides and herbicides.
• Academic Research: Serves as a starting material for novel methodological development in organic synthesis laboratories.

Basic Information

Product Name	(S)-1-Amino-2-Hydroxymethylindoline
CAS No.	27719-98-8
Molecular Formula	C9H12N2O
Molecular Weight	164.20 g/mol
Synonyms	(S)-1-Amino-2-(hydroxymethyl)indoline; (S)-2-(Aminomethyl)indolin-2-ol; (2S)-1-Amino-2-(hydroxymethyl)-2,3-dihydro-1H-indole; (S)-Indoline-1,2-dimethanol, 1-amino-; (S)-1,2-Dihydro-1-amino-2-(hydroxymethyl)indole; (S)-Aminomethylindolin-2-ol
EINECS	Contact for details

Quality Control

Our (S)-1-Amino-2-Hydroxymethylindoline is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.