Description

3-Chloro-1-(2-Trifluoromethyl-Phenothiazin-10-Yl)-Propan-1-One is a high-purity, advanced pharmaceutical intermediate with a distinct trifluoromethyl-phenothiazine core structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and psychotropic medications. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process chemistry for creating next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel phenothiazine-derived active pharmaceutical ingredients (APIs).
• Drug Discovery & Research: Used in medicinal chemistry for the research and development of new therapeutic compounds, particularly targeting neurological pathways.
• Process Chemistry: Serves as a critical precursor in the scale-up and optimization of manufacturing routes for complex drug molecules.
• Chemical Synthesis: Employed in organic synthesis to introduce the trifluoromethyl-phenothiazine moiety into more complex molecular architectures.
• Reference Standard: Can be used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	3-Chloro-1-(2-Trifluoromethyl-Phenothiazin-10-Yl)-Propan-1-One
CAS No.	27312-94-3
Molecular Formula	C₁₆H₁₀ClF₃NOS
Molecular Weight	368.77 g/mol
Synonyms	10-(3-Chloropropanoyl)-2-(trifluoromethyl)phenothiazine; 3-Chloro-1-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-one; 1-(3-Chloro-1-oxopropyl)-2-trifluoromethylphenothiazine; 2-Trifluoromethyl-10-(3-chloropropionyl)phenothiazine; 3-Chloro-1-(2-trifluoromethylphenothiazin-10-yl)-1-propanone; N-(3-Chloropropionyl)-2-trifluoromethylphenothiazine; 27312-94-3
EINECS	Contact for details

Quality Control

Our 3-Chloro-1-(2-Trifluoromethyl-Phenothiazin-10-Yl)-Propan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.