Description

N-(Chloroacetoxy)Succinimide is a versatile and highly reactive chemical intermediate, primarily used as an efficient acylating and chloroacetylating agent. Its core value proposition lies in its ability to introduce the chloroacetoxy functional group under mild conditions, enabling precise synthesis in complex organic transformations. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it serves as a critical building block for active pharmaceutical ingredients (APIs), fine chemicals, and advanced materials.

Application

• Pharmaceutical Synthesis: Key intermediate for the production of active pharmaceutical ingredients (APIs), particularly in the synthesis of antibiotics, antiviral agents, and other N-heterocyclic compounds.
• Peptide Chemistry & Bioconjugation: Used as a coupling reagent and for modifying amino acids or peptides, facilitating the creation of peptide-based drugs and diagnostic probes.
• Agrochemical Manufacturing: Serves as a precursor in the synthesis of herbicides, fungicides, and plant growth regulators that require the chloroacetamide moiety.
• Polymer & Material Science: Employed as a cross-linking agent or functional monomer to introduce reactive sites into polymers, resins, and advanced functional materials.
• Organic Synthesis Reagent: A valuable reagent for introducing protecting groups and for facilitating acylation reactions in complex multi-step synthetic routes.
• Biochemical Research: Utilized in proteomics and enzyme studies for labeling proteins or modifying enzyme active sites.

Basic Information

Product Name	N-(Chloroacetoxy)Succinimide
CAS No.	27243-15-8
Molecular Formula	C6H6ClNO4
Molecular Weight	191.57 g/mol
Synonyms	N-Chloroacetyloxysuccinimide; Chloroacetic Acid N-Hydroxysuccinimide Ester; N-Hydroxysuccinimidyl Chloroacetate; Succinimidyl Chloroacetate; NSC 113992; Chloroacetyloxysuccinimide; N-(Chloroacetyloxy)succinimide; 1-[(Chloroacetyl)oxy]-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our N-(Chloroacetoxy)Succinimide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for assay and purity, and is supplied with a comprehensive Certificate of Analysis (COA). We adhere to cGMP principles where applicable, ensuring the product meets the stringent requirements for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	108°C - 112°C
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.