Description

4-Bromo-Isoquinoline-1-Carbonitrile is a high-purity, versatile heterocyclic building block essential for advanced organic synthesis. Its molecular structure, featuring both bromo and cyano substituents, makes it a critical intermediate for constructing complex pharmacophores and functional materials. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to facilitate the development of new active compounds and specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used to develop new active ingredients for crop protection products, leveraging its halogenated quinoline scaffold.
• Material Science: Acts as a building block for creating organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig amination.
• Nucleophilic Substitution: The cyano group provides a site for further functionalization to amides, carboxylic acids, and heterocycles.

Basic Information

Product Name	4-Bromo-Isoquinoline-1-Carbonitrile
CAS No.	27224-09-5
Molecular Formula	C10H5BrN2
Molecular Weight	233.07 g/mol
Synonyms	4-Bromoisoquinoline-1-carbonitrile; 1-Cyano-4-bromoisoquinoline; 4-Bromo-1-cyanoisoquinoline; 4-Bromo-1-isoquinolinecarbonitrile; Isoquinoline-1-carbonitrile, 4-bromo-; 27224-09-5; 4-Br-IQ-1-CN
EINECS	Contact for details

Quality Control

Our 4-Bromo-Isoquinoline-1-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.