Description

S-Trityl-3-Mercaptopropionic Acid is a versatile and highly valuable protected thiol reagent used in organic synthesis and peptide chemistry. Its primary function is to provide a stable, trityl-protected mercaptopropionic acid moiety, which is crucial for the controlled introduction of thiol groups and the formation of disulfide bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries, particularly for the synthesis of peptides, protein conjugates, and complex organic molecules requiring precise thiol chemistry.

Application

• Peptide Synthesis: A key building block for introducing protected cysteine analogs or for creating thiol-containing peptide side chains.
• Bioconjugation: Used in the preparation of antibody-drug conjugates (ADCs), protein labeling, and the functionalization of biomolecules via thiol-maleimide or thiol-disulfide exchange chemistry.
• Organic Intermediate: Serves as a critical intermediate in the synthesis of complex pharmaceuticals, agrochemicals, and specialty chemicals requiring a protected thiol functionality.
• Polymer Modification: Employed to incorporate thiol groups into polymers and materials for cross-linking, surface modification, and creating responsive materials.
• Ligand Synthesis: Used in the preparation of chelating agents and ligands for catalysis and metal ion binding.
• Research & Development: A fundamental reagent in academic and industrial R&D labs for exploring new synthetic methodologies and bioactive compound development.

Basic Information

Product Name	S-Trityl-3-Mercaptopropionic Acid
CAS No.	27144-18-9
Molecular Formula	C22H20O2S
Molecular Weight	348.46 g/mol
Synonyms	3-[(Triphenylmethyl)thio]propanoic Acid; Tritylmercaptopropionic Acid; S-Trityl-β-mercaptopropionic Acid; (3-Carboxypropyl)triphenylmethyl Sulfide; STMPA; NSC 334365; Triphenylmethyl 3-mercaptopropionate; 3-(Tritylthio)propionic Acid
EINECS	Contact for details

Quality Control

Our S-Trityl-3-Mercaptopropionic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay (HPLC), identity (IR, NMR), and impurity profiles. Our quality system is designed to meet the rigorous standards required for pharmaceutical intermediate and research-grade chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	97 - 102 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.