Description

(-)- (1R, 2S)-(1, 2-Epoxypropyl)Phosphonic Acid CAS NO 26469-67-0 is a high-purity, chiral organophosphorus compound characterized by its reactive epoxide and phosphonic acid functional groups. This unique structure makes it a versatile and critical chiral building block for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is essential for chemists and R&D teams developing novel active pharmaceutical ingredients (APIs), bioactive probes, and specialty fine chemicals where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of phosphate-containing drugs, enzyme inhibitors, and prodrugs.
• Agrochemical Synthesis: Used in the research and production of chiral herbicides, fungicides, and plant growth regulators with enhanced activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral phosphonate ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Biochemical Research: Employed in the synthesis of labeled compounds, metabolic pathway probes, and biomimetic materials.
• Material Science: Utilized as a monomer or cross-linking agent for specialty polymers, coatings, and adhesives with specific functional properties.
• Chemical Biology: Acts as a tool compound for studying phosphonate biochemistry and enzyme mechanisms.

Basic Information

Product Name	(-)- (1R, 2S)-(1, 2-Epoxypropyl)Phosphonic Acid
CAS No.	26469-67-0
Molecular Formula	C₃H₇O₄P
Molecular Weight	138.06 g/mol
Synonyms	(1R,2S)-1,2-Epoxypropylphosphonic Acid; (R)-(-)-1,2-Epoxypropylphosphonic Acid; L-(+)-1,2-Epoxypropylphosphonic Acid (enantiomer); Fosfomycin Intermediate; (1R,2S)-Epoxypropylphosphonate; Phosphonic acid, P-[(1R,2S)-1,2-epoxypropyl]-; (-)-cis-1,2-Epoxypropylphosphonic Acid
EINECS	Contact for details

Quality Control

Our production of (-)- (1R, 2S)-(1, 2-Epoxypropyl)Phosphonic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.