Description

Triethyl Orthoformate-D1 is a deuterated derivative of triethyl orthoformate, a key reagent in organic synthesis. This compound is valued for its role as a stable deuterium source and a versatile building block in the preparation of complex molecules, particularly in pharmaceutical research. It is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, isotopically labeled intermediates.

Application

• Pharmaceutical Intermediate: Used as a deuterium-labeled synthon in the synthesis of active pharmaceutical ingredients (APIs) for drug discovery and development.
• Agrochemical Synthesis: Serves as a precursor in the manufacturing of deuterated pesticides and herbicides to study metabolic pathways and environmental fate.
• Material Science: Employed in the production of specialty polymers and advanced organic electronic materials where deuterium incorporation is required.
• NMR Spectroscopy: Acts as a useful deuterated solvent or internal standard in nuclear magnetic resonance (NMR) analysis.
• Organic Synthesis: Functions as a protected formyl anion equivalent and a reagent for introducing the -CD(OC₂H₅)₃ group in various condensation and cyclization reactions.
• Isotope Labeling Studies: Critical for metabolic stability testing, pharmacokinetic (PK) studies, and tracing reaction mechanisms in academic and industrial research.

Basic Information

Product Name	Triethyl Orthoformate-D1
CAS No.	26387-53-1
Molecular Formula	C₇H₁₅D₃O₃
Molecular Weight	162.23 g/mol
Synonyms	Deuterated Triethyl Orthoformate; Triethyl Orthoformate-d3; Orthoformic Acid Triethyl Ester-d3; Ethyl Orthoformate-d3; 1,1,1-Triethoxy-d3-methane; HC(OC₂H₅)₃-d3; Formic Acid, Triethyl Ester, D-labeled; Triethoxymethane-d3
EINECS	Contact for details

Quality Control

Our Triethyl Orthoformate-D1 is produced under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot undergoes comprehensive analysis, including assay by NMR or GC-MS, deuterium enrichment verification, and impurity profiling. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Deuterium Enrichment (NMR)	≥ 98 atom % D
Water Content (KF)	≤ 0.1%
Residue on Ignition	≤ 0.05%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.