Description

((4-Bromophenyl)[Bis(Trimethylsilyl)]Methyl)(Trimethyl)Silane is a highly functionalized organosilicon compound, specifically a silyl-protected benzyl bromide derivative, that serves as a versatile and valuable synthetic building block. Its core value proposition lies in its unique structure, which combines a reactive bromophenyl group with robust trimethylsilyl protecting groups, enabling precise and controlled chemical transformations. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require sophisticated intermediates for constructing complex molecular architectures, such as in the synthesis of active pharmaceutical ingredients (APIs) and liquid crystal materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly where silyl-protected aromatic systems are required for selective coupling reactions.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the reactivity of the bromine atom for constructing heterocyclic or substituted aromatic cores.
• Advanced Materials Chemistry: Serves as a monomer or functionalizing agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Negishi) due to the presence of the aryl bromide moiety.
• Organometallic Reagent Preparation: Used to generate highly reactive organolithium or Grignard reagents for nucleophilic addition reactions.
• Protecting Group Strategy: The bis(trimethylsilyl)methyl group can act as a protecting group for alcohols or other functionalities in multi-step synthetic sequences.

Basic Information

Product Name	((4-Bromophenyl)[Bis(Trimethylsilyl)]Methyl)(Trimethyl)Silane
CAS No.	26167-15-7
Molecular Formula	C16H31BrSi3
Molecular Weight	387.58 g/mol
Synonyms	1-((4-Bromophenyl)bis(trimethylsilyl)methyl)-1,1,1-trimethylsilane; (4-Bromobenzyl)bis(trimethylsilyl)(trimethylsilyl)methane; Trimethyl[(4-bromophenyl)bis(trimethylsilyl)methyl]silane; Bromophenyltris(trimethylsilyl)methane derivative; TMS-protected 4-bromobenzyl silane; Silicon-protected bromobenzyl reagent; (p-Bromophenyl)tris(trimethylsilyl)methane
EINECS	Contact for details

Quality Control

Our production of ((4-Bromophenyl)[Bis(Trimethylsilyl)]Methyl)(Trimethyl)Silane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing, including NMR (¹H, ¹³C), GC/HPLC, and elemental analysis, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We operate under a quality management system and can support development projects requiring compliance with cGMP or other regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.