Description

Z-L-Phenylalanine n-Carboxyanhydride is a high-purity, protected amino acid derivative essential for controlled peptide synthesis. This compound serves as a critical building block, enabling the efficient and sequential addition of phenylalanine residues in solid-phase and solution-phase methodologies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioactive compounds. The product, identified by CAS NO 25613-60-9, offers reliable performance for advanced organic synthesis applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the controlled, stepwise elongation of peptide chains on resin supports.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for constructing specific peptide sequences in solution.
• Research & Development of Bioactive Peptides: Essential for synthesizing peptide analogs for structure-activity relationship (SAR) studies in drug discovery.
• Production of Custom Peptides and Oligomers: Enables the manufacture of specialized peptides for diagnostic, therapeutic, and biochemical research.
• Synthesis of Peptidomimetics: Acts as a precursor for creating non-peptide compounds that mimic peptide bioactivity.
• Material Science: Potential use in the synthesis of peptide-polymer conjugates and advanced biomaterials.

Basic Information

Product Name	Z-L-Phenylalanine n-Carboxyanhydride
CAS No.	25613-60-9
Molecular Formula	C17H15NO5
Molecular Weight	313.31 g/mol
Synonyms	N-Carboxybenzyl-L-phenylalanine anhydride; Z-Phe-NCA; NCA-Z-Phenylalanine; (S)-5-Oxo-4-(3-phenyl-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)propanoyl)oxazolidine-3-carboxylic acid; Benzyloxycarbonyl-L-phenylalanine N-carboxyanhydride; Z-L-Phe-NCA; Fmoc-Phe-NCA (Note: Common but technically incorrect for Z-protected); N-(Benzyloxycarbonyl)-L-phenylalanine N-carboxyanhydride
EINECS	Contact for details

Quality Control

Our Z-L-Phenylalanine n-Carboxyanhydride is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and chiral analysis to confirm enantiomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at temperatures between 2°C and 8°C (refrigerated) for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in THF, DMF, DMSO; sparingly soluble in diethyl ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.