Description

α-(Trimethylsilyloxy)Phenylacetonitrile is a versatile organosilicon reagent featuring a protected cyanohydrin functionality. This compound is a critical building block in organic synthesis, valued for its role in introducing the phenylacetonitrile moiety under mild conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of β-blockers, antidepressants, and other nitrogen-containing bioactive compounds.
• Fine Chemical Synthesis: Used in the preparation of specialty chemicals, flavors, and fragrances requiring the phenylacetonitrile backbone.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides and insecticides.
• Material Science: Employed in the synthesis of monomers or modifiers for advanced polymers and silicones.
• Academic & R&D Laboratories: A valuable reagent for methodological development in synthetic organic chemistry, particularly in cyanohydrin chemistry and nucleophilic addition reactions.

Basic Information

Product Name	α-(Trimethylsilyloxy)Phenylacetonitrile
CAS No.	25438-37-3
Molecular Formula	C11H15NOSi
Molecular Weight	205.33 g/mol
Synonyms	2-(Trimethylsilyloxy)-2-phenylacetonitrile; (Trimethylsilyloxy)(phenyl)acetonitrile; Phenyl(trimethylsilyloxy)acetonitrile; α-(Trimethylsiloxy)benzyl cyanide; TMSCN Adduct with Benzaldehyde; Benzaldehyde cyanohydrin trimethylsilyl ether; NSC 334048; (Phenyl)(trimethylsilyloxy)acetonitrile
EINECS	Contact for details

Quality Control

Our α-(Trimethylsilyloxy)Phenylacetonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and GC-MS characterization. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each batch to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.