Description

n-(Phenyl)Glycine Trimethylsilyl Ester is a specialized organosilicon-protected amino acid derivative, serving as a crucial building block in advanced organic synthesis. Its primary value lies in its role as a protected glycine equivalent, enabling the controlled introduction of the phenylglycine moiety under mild conditions where the free amino acid would be incompatible. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of peptides, peptidomimetics, and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of β-lactam antibiotics and other active pharmaceutical ingredients (APIs) containing phenylglycine structures.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to construct complex peptide sequences.
• Asymmetric Synthesis: Employed in chiral synthesis routes to produce enantiomerically pure compounds for drug discovery and development.
• Ligand and Catalyst Preparation: Serves as a precursor for nitrogen-containing ligands used in transition metal catalysis.
• Material Science Research: Utilized in the development of novel organic frameworks and functional materials.
• Agrochemical Synthesis: Intermediate in the production of certain herbicides and plant growth regulators.

Basic Information

Product Name	n-(Phenyl)Glycine Trimethylsilyl Ester
CAS No.	25436-41-3
Molecular Formula	C11H17NO2Si
Molecular Weight	223.35 g/mol
Synonyms	Trimethylsilyl N-Phenylglycinate; N-(Trimethylsilyl)-N-phenylglycine; Phenylglycine Trimethylsilyl Ester; (Trimethylsilyl)phenylglycinate; Glycine, N-phenyl-, trimethylsilyl ester; N-Phenylglycine TMS Ester; 2-((Trimethylsilyl)amino)-2-phenylacetic acid; (Phenylamino)acetic acid trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our n-(Phenyl)Glycine Trimethylsilyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC analysis, to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.