Description

Uracil-5,6-D2 is a deuterium-labeled isotopologue of the fundamental pyrimidine nucleobase uracil, specifically deuterated at the 5 and 6 positions. This compound is essential for advanced research and development, providing a stable, non-radioactive isotopic tracer for mechanistic studies in biochemistry and pharmacology. It is primarily utilized by scientists and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry industries for applications such as metabolic pathway analysis, drug discovery, and as an internal standard in mass spectrometry.

Application

• Metabolic and Pharmacokinetic Studies: Used as a stable isotopic tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of uracil and related compounds.
• Drug Discovery & Development: Serves as a key building block or probe in the synthesis of deuterated drug candidates, potentially enhancing metabolic stability and pharmacokinetic profiles.
• Analytical Chemistry Standard: Employed as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of uracil in complex biological matrices.
• Biochemical Research: A vital tool for studying nucleic acid chemistry, enzyme mechanisms (e.g., involving dihydropyrimidine dehydrogenase), and nucleotide salvage pathways.
• Agrochemical Research: Used in the development and environmental fate studies of novel pesticides and herbicides that target pyrimidine metabolism in plants and pests.

Basic Information

Product Name	Uracil-5,6-D2
CAS No.	24897-52-7
Molecular Formula	C4H2D2N2O2
Molecular Weight	114.10 g/mol
Synonyms	2,4-Dihydroxypyrimidine-5,6-d2; 5,6-Dideuteriouracil; Uracil-d2; [5,6-2H2]Uracil; 2,4(1H,3H)-Pyrimidinedione-5,6-d2; NSC 27420-d2; Deuterated Uracil
EINECS	Contact for details

Quality Control

Our Uracil-5,6-D2 is produced and tested under strict quality management protocols. Each batch undergoes comprehensive analysis to ensure high chemical purity and isotopic enrichment, with specifications typically meeting or exceeding research-grade standards. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (by HPLC), isotopic enrichment (by NMR/MS), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.