Description

Uracil-6-D1 is a deuterium-labeled isotopologue of the fundamental pyrimidine nucleobase uracil, specifically deuterated at the 6-position. This stable isotope-labeled compound is critical for advanced analytical and research applications where precise molecular tracking is required. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors for use as an internal standard in mass spectrometry, metabolic studies, and the synthesis of labeled nucleic acids.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of uracil and related metabolites in complex biological matrices like plasma, urine, and tissue samples.
• Metabolic Pathway Tracing: Used in pharmacokinetic and drug metabolism studies to track the absorption, distribution, metabolism, and excretion (ADME) of nucleobase-based compounds.
• Synthesis of Labeled Biomolecules: Serves as a key building block for the preparation of deuterium-labeled nucleotides, nucleosides, and oligonucleotides for structural and mechanistic research.
• Proteomics and Biomarker Research: Facilitates stable isotope labeling strategies for the relative and absolute quantification of proteins and nucleic acids.
• Quality Control Reference Material: Employed in analytical laboratories to validate methods and ensure the accuracy and precision of assays for uracil and its derivatives.
• Environmental Fate Studies: Applied in agrochemical research to study the degradation and environmental behavior of pyrimidine-based compounds.

Basic Information

Product Name	Uracil-6-D1
CAS No.	24897-51-6
Molecular Formula	C₄H₃D₁N₂O₂
Molecular Weight	113.08 g/mol
Synonyms	6-Deuteriouracil; [6-²H]Uracil; Uracil-d1; 2,4-Dihydroxypyrimidine-6-d1; 6-D-Uracil; Uracil (6-D); 6-Deutero-2,4(1H,3H)-pyrimidinedione
EINECS	Contact for details

Quality Control

Our Uracil-6-D1 is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (deuterium incorporation), and identity confirmation. We adhere to cGMP principles for consistent production, and our quality system is designed to meet the stringent requirements of research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.