Description

1,3-Dichloro-5-Methoxyisoquinoline is a versatile and high-value heterocyclic building block used in advanced organic synthesis. Its unique halogenated isoquinoline structure makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), specialty agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Serves as a building block for developing new-generation herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Used in the development of organic light-emitting diodes (OLEDs), liquid crystals, and other functional organic materials due to its electron-deficient aromatic system.
• Chemical Biology & Proteomics: Employed as a reactive handle or scaffold in the design of molecular probes, enzyme inhibitors, and bioconjugation reagents.
• Academic & Contract Research: Essential reagent for methodological development in organic chemistry, including cross-coupling reactions and heterocyclic chemistry studies.
• Custom Synthesis & Scale-Up: Supplied for contract manufacturing and process optimization projects from gram to multi-kilogram scale.

Basic Information

Product Name	1,3-Dichloro-5-Methoxyisoquinoline
CAS No.	24623-38-9
Molecular Formula	C₁₀H₇Cl₂NO
Molecular Weight	228.08 g/mol
Synonyms	5-Methoxy-1,3-dichloroisoquinoline; 1,3-Dichloro-5-methoxy-isoquinoline; Isoquinoline, 1,3-dichloro-5-methoxy-; 24623-38-9; 5-Methoxy-1,3-dichloro-isoquinoline; 1,3-Dichloro-5-methoxyisoquinoline; 1,3-Dichloro-5-methoxy-isoquinoline
EINECS	Contact for details

Quality Control

Our 1,3-Dichloro-5-Methoxyisoquinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.