Description

3-(Trimethylsilyl)-1H-Pyrazole is a versatile organosilicon-protected pyrazole derivative, serving as a crucial building block in advanced organic synthesis. Its primary value lies in its role as a protected intermediate, enabling the selective functionalization of the pyrazole ring system under conditions where the unprotected heterocycle would be unstable or reactive. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients, ligands, and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of novel drug candidates, especially those containing pyrazole-based pharmacophores.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the pyrazole moiety is a core structural element.
• Ligand Precursor: Serves as a protected starting material for the synthesis of N-heterocyclic carbene (NHC) ligands and other coordination compounds in catalysis.
• Material Science Research: Employed in the development of organic semiconductors, metal-organic frameworks (MOFs), and other functional organic materials.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions, such as Suzuki or Buchwald-Hartwig amination, after deprotection.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems.

Basic Information

Product Name	3-(Trimethylsilyl)-1H-Pyrazole
CAS No.	24602-40-2
Molecular Formula	C6H12N2Si
Molecular Weight	140.26 g/mol
Synonyms	1H-Pyrazole, 3-(trimethylsilyl)-; 3-Trimethylsilylpyrazole; 3-TMS-Pyrazole; 3-(Trimethylsilyl)pyrazole; Pyrazole, 3-(trimethylsilyl)-; Trimethyl(1H-pyrazol-3-yl)silane; 3-Pyrazolyltrimethylsilane
EINECS	Contact for details

Quality Control

Every batch of 3-(Trimethylsilyl)-1H-Pyrazole is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive analytical data, including HPLC purity, NMR confirmation, and identity verification. A Certificate of Analysis (COA) is supplied with each shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP manufacturing requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.