Description

(8As)-6,7-Bis(3,4-Dimethoxyphenyl)-1,2,3,5,8,8A-Hexahydroindolizine CAS NO 24316-18-5 is a complex, high-purity indolizine derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical chiral intermediate and building block for the development of novel bioactive molecules. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Synthesis: Utilized as a sophisticated building block in stereoselective synthesis to construct complex molecular architectures with defined chirality.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the generation of compound libraries for high-throughput screening.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, agrochemicals, and other high-value indolizine-based derivatives.
• Academic & Institutional Research: Used in universities and research institutes for studies in organic methodology development and heterocyclic chemistry.

Basic Information

Product Name	(8As)-6,7-Bis(3,4-Dimethoxyphenyl)-1,2,3,5,8,8A-Hexahydroindolizine
CAS No.	24316-18-5
Molecular Formula	C26H31NO4
Molecular Weight	421.53 g/mol
Synonyms	6,7-Bis(3,4-dimethoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine; (8aR)-6,7-Bis(3,4-dimethoxyphenyl)octahydroindolizine; Indolizine, 6,7-bis(3,4-dimethoxyphenyl)-1,2,3,5,8,8a-hexahydro-; (8aS)-6,7-Bis(3,4-dimethoxyphenyl)octahydroindolizine; Hexahydroindolizine derivative; DMHP-Indolizine; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (8As)-6,7-Bis(3,4-Dimethoxyphenyl)-1,2,3,5,8,8A-Hexahydroindolizine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be sensitive to prolonged exposure to air and moisture; for long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.