Description

D-Ephedrine Hydrochloride is a high-purity, single-enantiomer salt form of the alkaloid ephedrine, specifically the (1R,2S)-(-)-ephedrine enantiomer. This compound is a critical chiral intermediate and active pharmaceutical ingredient (API) valued for its precise stereochemistry and pharmacological activity. It is essential for manufacturers in the pharmaceutical, research, and fine chemical synthesis sectors requiring a defined enantiomeric profile for the development of decongestants, bronchodilators, and other specialized adrenergic agents.

Application

• Pharmaceutical API Synthesis: Serves as a key chiral building block and active ingredient in prescription and over-the-counter medications, primarily for nasal decongestants and bronchodilators.
• Reference Standard & Analytical Testing: Used as a certified reference material (CRM) in quality control laboratories for HPLC, GC, or spectroscopic method development and validation.
• Biochemical & Pharmacological Research: Employed in academic and industrial R&D for studying adrenergic receptor mechanisms, metabolic pathways, and chiral pharmacology.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or resolving agent in the synthesis of other enantiomerically pure compounds.
• Veterinary Pharmaceuticals: Incorporated into formulations for respiratory treatments in animals.

Basic Information

Product Name	D-Ephedrine Hydrochloride
CAS No.	24221-86-1
Molecular Formula	C10H15NO·HCl
Molecular Weight	201.69 g/mol
Synonyms	(-)-Ephedrine Hydrochloride; (1R,2S)-(-)-Ephedrine Hydrochloride; l-Ephedrine Hydrochloride; Levorephedrine Hydrochloride; Ephedrine HCl; D-(-)-Ephedrine Hydrochloride; 2-Methylamino-1-phenylpropan-1-ol Hydrochloride; Erythro-(-)-Ephedrine Hydrochloride
EINECS	Contact for details

Quality Control

Our D-Ephedrine Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure compliance with high-purity standards, including rigorous checks for identity, potency, and enantiomeric purity. Certificates of Analysis (COA) detailing specific results for assay, related substances, residual solvents, and chiral purity are provided with every shipment. We support compliance with cGMP, ICH guidelines, and relevant pharmacopoeial standards (e.g., USP, EP) for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to prevent clumping or degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.