Description

Tetramethyl-D12-Ammonium Chloride is a fully deuterated isotopologue of tetramethylammonium chloride, where all twelve hydrogen atoms are replaced by deuterium. This compound is a critical reagent in advanced analytical chemistry, particularly for Nuclear Magnetic Resonance (NMR) spectroscopy, where it serves as an essential chemical shift reference and locking agent. It is indispensable for researchers and quality control laboratories in the pharmaceutical, agrochemical, and academic sectors requiring high-precision deuterium-labeled standards.

Application

• Primary internal standard and chemical shift reference (δ = 3.18 ppm in D2O) for ¹H and ¹³C NMR spectroscopy.
• Locking agent for stabilizing the magnetic field in high-resolution NMR spectrometers.
• Deuterium-labeled standard for quantitative NMR (qNMR) method development and validation.
• Essential reagent in the synthesis and analysis of deuterated compounds for metabolic and pharmacokinetic studies.
• Used in analytical method development within pharmaceutical R&D and quality control laboratories.
• Reference material for instrument calibration and performance verification in analytical chemistry.

Basic Information

Product Name	Tetramethyl-D12-Ammonium Chloride
CAS No.	23789-03-9
Molecular Formula	C4D12ClN
Molecular Weight	125.68 g/mol
Synonyms	Tetramethylammonium-d12 Chloride; Deuterated Tetramethylammonium Chloride; N,N,N-Trimethyl-d9-methanaminium-d3 Chloride; Perdeuterotetramethylammonium Chloride; TMA-d12 Chloride; TMAC-d12; NMR Reference Standard; (CD3)4NCl
EINECS	Contact for details

Quality Control

Our Tetramethyl-D12-Ammonium Chloride is manufactured under controlled conditions to ensure exceptional isotopic purity and chemical integrity, meeting the stringent requirements of analytical reference standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (D-atom %), assay, and impurity profiles. We adhere to rigorous quality testing protocols to guarantee batch-to-batch consistency and reliability for your most critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0 %
Isotopic Purity (D-atom %)	≥ 99.0 % (by 1H NMR)
Water Content (KF)	≤ 1.0 %
Solubility (in D2O)	Clear, colorless solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.