Description

2-Chloro-1,6-Naphthyridine is a versatile halogenated heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in serving as a key intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of potential drug candidates, especially kinase inhibitors and other biologically active naphthyridine derivatives.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides where the naphthyridine scaffold imparts specific biological activity.
• Ligand Synthesis: Serves as a starting material for creating novel chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the research of organic electronic materials, such as semiconductors and light-emitting compounds, due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: The chloro substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig aminations for carbon-carbon and carbon-heteroatom bond formation.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular processes.

Basic Information

Product Name	2-Chloro-1,6-Naphthyridine
CAS No.	23616-33-3
Molecular Formula	C8H5ClN2
Molecular Weight	164.59 g/mol
Synonyms	2-Chloro-1,6-naphthyridine; 1,6-Naphthyridine, 2-chloro-; 2-Chloro-1,6-diazanaphthalene; 2-Chloro[1,6]naphthyridine; 2-Chloro-1,6-naphthyridine (CAS 23616-33-3); 2-Cl-1,6-Naphthyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-1,6-Naphthyridine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.