Description

10-Methoxy-6-Methylergoline-8α-Carboxamide is a high-purity ergoline derivative, a key intermediate in advanced pharmaceutical synthesis. This compound is valued for its structural role in the development of specialized active pharmaceutical ingredients (APIs) targeting neurological and cardiovascular pathways. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex ergot alkaloid-derived APIs.
• Neurological Research: Used in preclinical studies for investigating compounds that interact with serotonin and dopamine receptor systems.
• Cardiovascular Drug Development: Serves as a precursor in the research of vasoactive and anti-migraine medications.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Process Chemistry: Utilized in route scouting and scale-up optimization for new chemical entities (NCEs).
• Biochemical Research: Applied in studies exploring the structure-activity relationships (SAR) of ergoline scaffolds.

Basic Information

Product Name	10-Methoxy-6-Methylergoline-8α-Carboxamide
CAS No.	23495-53-6
Molecular Formula	C19H23N3O2
Molecular Weight	325.41 g/mol
Synonyms	10-Methoxy-6-methylergoline-8α-carboxamide; 8α-Carbamoyl-10-methoxy-6-methylergoline; 10-Methoxy-6-methyl-8α-ergolinecarboxamide; 10-Methoxy-6-methyl-8α-carbamoylergoline; 10-Methoxy-6-methylergoline-8α-carboxylic acid amide; 23495-53-6; 10-Methoxy-6-methyl-8α-ergolinecarboxylic acid amide
EINECS	Contact for details

Quality Control

Our 10-Methoxy-6-Methylergoline-8α-Carboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect this light-sensitive material.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.