Description

2-(Trimethylsilyl)-5-Chlorothiophene is a high-value organosilicon-thiophene hybrid compound, serving as a critical building block in advanced organic synthesis. Its unique structure, combining a silyl protecting group with a halogenated heterocycle, makes it indispensable for constructing complex molecules with precise electronic and steric properties. This specialty chemical is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediates: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and anti-infective therapies.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, and insecticides, where the thiophene moiety contributes to biological activity.
• Organic Electronic Materials: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Ligand & Catalyst Development: Employed in the synthesis of sophisticated ligands for transition metal catalysis, enabling challenging cross-coupling and C-H activation reactions.
• Chemical Research & Development: A versatile reagent for method development in organic synthesis, including palladium-catalyzed cross-couplings like Stille and Suzuki reactions.
• Functional Material Precursors: Building block for creating specialty monomers and polymers with tailored thermal, optical, or conductive properties.

Basic Information

Item	Detail
Product Name	2-(Trimethylsilyl)-5-Chlorothiophene
CAS No.	23395-56-4
Molecular Formula	C7H11ClSSi
Molecular Weight	190.77 g/mol
Synonyms	5-Chloro-2-(trimethylsilyl)thiophene; 5-Chloro-2-trimethylsilylthiophene; 2-Chloro-5-(trimethylsilyl)thiophene (isomer); Thiophene, 5-chloro-2-(trimethylsilyl)-; TMS-Chlorothiophene; 2-TMS-5-Chlorothiophene; 2-(Trimethylsilyl)-5-chlorothiophene; 23395-56-4
EINECS	Contact for details

Quality Control

Every batch of 2-(Trimethylsilyl)-5-Chlorothiophene is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC, HPLC, and NMR is supplied with each shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.