Description

Nefopam Hydrochloride CAS NO 23327-57-3 is a non-opioid, centrally acting analgesic compound used for the management of moderate to severe pain. Its primary value lies in providing effective pain relief through a distinct mechanism of action, offering an alternative to traditional opioid therapies. This makes it a critical active pharmaceutical ingredient (API) for pharmaceutical manufacturers developing analgesic formulations, particularly for postoperative pain, musculoskeletal pain, and neuropathic pain management.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of analgesic tablets, capsules, and injectable solutions.
• Postoperative Pain Management: Formulated into medications for controlling pain following surgical procedures.
• Chronic Pain Therapy: Used in medications for long-term management of conditions like musculoskeletal pain and neuropathic pain.
• Non-Opioid Analgesic Development: Serves as a key compound in R&D for creating new pain relief drugs with a reduced risk of opioid-related side effects and dependency.
• Combination Drug Formulations: Can be combined with other analgesic agents in multi-ingredient pharmaceutical products.
• Clinical Research: Utilized as a reference standard in pharmacological studies and clinical trials investigating pain pathways and analgesic efficacy.

Basic Information

Product Name	Nefopam Hydrochloride
CAS No.	23327-57-3
Molecular Formula	C17H19NO • HCl
Molecular Weight	289.80 g/mol
Synonyms	Nefopam HCl; Fenazoxine Hydrochloride; Acupan (brand name); 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine Hydrochloride; Benzoxazocine; Ajan; Nefopami Hydrochloridum
EINECS	Contact for details

Quality Control

Our Nefopam Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. We provide Certificates of Analysis (COA) with detailed results for parameters including assay, related substances, residual solvents, and identification. Specifications can be aligned with pharmacopeial standards (such as USP or EP) upon request to meet specific regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5%; Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.