Description

Dimethyl Fumarate-2,3-D2 is a deuterated analog of dimethyl fumarate, a compound of significant interest in pharmaceutical research and development. This isotopically labeled version is specifically designed for use as an internal standard in quantitative mass spectrometry, enhancing the accuracy and reliability of analytical data. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise metabolic and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, non-interfering internal standard for the precise quantification of dimethyl fumarate and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for tracing the absorption, distribution, metabolism, and excretion (ADME) profiles of dimethyl fumarate in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate robust, regulatory-compliant (FDA, EMA) bioanalytical assays.
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly accurate and precise measurements, minimizing matrix effects and instrument variability.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of potential deuterated impurities or related substances in active pharmaceutical ingredient (API) batches.
• Mechanistic Studies: Facilitates research into the biochemical pathways and mechanisms of action of fumarate-based therapeutics.

Basic Information

Product Name	Dimethyl Fumarate-2,3-D2
CAS No.	23057-98-9
Molecular Formula	C6H6D2O4
Molecular Weight	146.15 g/mol
Synonyms	(E)-2,3-Dideuterio-but-2-enedioic acid dimethyl ester; Dimethyl (E)-2,3-dideuteriobut-2-enedioate; Fumaric acid-2,3-d2 dimethyl ester; DMF-d2; Deuterated dimethyl fumarate; Dimethyl (2E)-2,3-Dideuteriobut-2-enedioate; Methyl hydrogen fumarate-2,3-d2 methyl ester
EINECS	Contact for details

Quality Control

Every batch of Dimethyl Fumarate-2,3-D2 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive analytical applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting critical parameters such as isotopic purity (deuterium enrichment), chemical purity, and identity confirmation. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. Keep the container tightly sealed to prevent moisture absorption and potential isotopic exchange.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.