Description

1-Propylthymine is a modified nucleobase derivative, specifically a thymine analog with a propyl substituent. This structural modification is critical for researchers developing novel nucleoside analogs and oligonucleotides with tailored properties. It serves as a key synthetic intermediate and building block in pharmaceutical research, particularly for antiviral and anticancer drug discovery programs. The compound is essential for scientists in medicinal chemistry and molecular biology seeking to modulate nucleic acid interactions and stability.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Oligonucleotide Synthesis: Used in the preparation of modified DNA/RNA strands for antisense therapy, siRNA, and diagnostic probes.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Biochemical Tool Development: Employed in creating labeled nucleotides or probes for studying enzyme mechanisms like polymerase activity.
• Academic & Industrial R&D: Fundamental research material for investigating nucleic acid chemistry, base-pairing fidelity, and novel biomaterials.

Basic Information

Product Name	1-Propylthymine
CAS No.	22919-49-9
Molecular Formula	C8H12N2O2
Molecular Weight	168.19 g/mol
Synonyms	1-Propyl-2,4-dihydroxypyrimidine; 1-Propyl-5-methyluracil; 5-Methyl-1-propyluracil; 1-Propyl-5-methyl-2,4(1H,3H)-pyrimidinedione; Thymine, 1-propyl-; N-Propylthymine; 1-Propylthymine (CAS 22919-49-9)
EINECS	Contact for details

Quality Control

Our 1-Propylthymine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Our quality commitment supports applications requiring high-purity synthetic intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.