Description

n-Methyl-N,o-Bis(trimethylsilyl)hydroxylamine is a specialized organosilicon reagent featuring a protected hydroxylamine functionality. This compound is valued for its role as a versatile silylating agent and a key synthon in the synthesis of complex nitrogen-containing molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of N-O containing heterocycles and active pharmaceutical ingredients (APIs).
• Silylating Agent: Used to introduce trimethylsilyl (TMS) protecting groups onto hydroxylamines and other sensitive functionalities during multi-step organic synthesis.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides requiring specific nitrogen-oxygen bonds.
• Material Science Research: Serves as a precursor in the development of silicon-based polymers and advanced functional materials.
• Cross-Coupling Reactions: Acts as a nitrogen source in metal-catalyzed cross-coupling methodologies to form C-N bonds.
• Academic & Industrial R&D: A valuable reagent for methodological development and exploring new reaction pathways in synthetic chemistry laboratories.

Basic Information

Product Name	n-Methyl-N,o-Bis(trimethylsilyl)hydroxylamine
CAS No.	22737-33-3
Molecular Formula	C7H21NOSi2
Molecular Weight	191.42 g/mol
Synonyms	N-Methyl-N,O-bis(trimethylsilyl)hydroxylamine; O,N-Bis(trimethylsilyl)-N-methylhydroxylamine; N-Methoxy-N-(trimethylsilyl)trimethylsilylamine; TMS-protected N-methylhydroxylamine; N,O-Bis(trimethylsilyl)-N-methylhydroxylamine; Methylhydroxylamine N,O-bis(trimethylsilyl) ether; 1-Methoxy-1-(trimethylsilyloxy)-N-(trimethylsilyl)methanamine
EINECS	Contact for details

Quality Control

Our n-Methyl-N,o-Bis(trimethylsilyl)hydroxylamine is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot undergoes comprehensive analytical testing including GC, NMR, and FT-IR for identity and purity verification. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.