Description

Symphytine is a pyrrolizidine alkaloid (PA) isolated from plants of the *Symphytum* (comfrey) genus. This compound is of significant interest in research and development due to its distinct chemical structure, which serves as a key reference standard for analytical and phytochemical studies. It is primarily utilized by professionals in the pharmaceutical, nutraceutical, and analytical chemistry sectors who require high-purity natural product isolates for quality control, method validation, and toxicological research.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of pyrrolizidine alkaloids in herbal medicines and dietary supplements.
• Analytical Research: Serves as a critical standard in HPLC, LC-MS, and GC-MS methods for the detection and analysis of hepatotoxic PAs in complex matrices.
• Toxicological Studies: Employed in research to investigate the metabolism, pharmacokinetics, and hepatotoxic mechanisms of pyrrolizidine alkaloids.
• Phytochemical Profiling: Essential for the chemical fingerprinting and standardization of botanical extracts derived from comfrey and related species.
• Quality Control (QC) Laboratories: Used to validate analytical procedures and ensure compliance with regulatory guidelines concerning PA limits in consumer products.
• Academic Research: A vital tool for studies in natural product chemistry, plant biochemistry, and the biosynthesis of secondary metabolites.

Basic Information

Product Name	Symphytine
CAS No.	22571-95-5
Molecular Formula	C20H31NO6
Molecular Weight	381.47 g/mol
Synonyms	7-Angeloylretronecine-9-senecioyl ester; 7-Angeloylretronecine-9-(3-methylbut-2-enoyl) ester; (1R,7aR)-1-[(2Z)-2-Methylbut-2-enoyl]oxy-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl (2Z)-2-methylbut-2-enoate; Symphytine alkaloid; Comfrey alkaloid
EINECS	Contact for details

Quality Control

Our Symphytine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the high standards required for research and reference materials. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.