Description

Methyl 2-(Acetylamino)-5-Chloro-3-Thiophenecarboxylate is a high-purity, specialized organic intermediate of significant importance in advanced chemical synthesis. Its core value lies in its role as a key building block for constructing complex heterocyclic molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development teams working on active pharmaceutical ingredients (APIs), crop protection agents, and novel materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic small molecules.
• Agrochemical Synthesis: Serves as a key building block for developing advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene core.
• Material Science Research: Used in the development of organic semiconductors, conductive polymers, and other functional materials due to its electron-rich thiophene structure.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new heterocyclic chemistry, reaction pathways, and as a standard for analytical method development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules in multi-step synthesis projects.

Basic Information

Product Name	Methyl 2-(Acetylamino)-5-Chloro-3-Thiophenecarboxylate
CAS No.	22288-82-0
Molecular Formula	C8H8ClNO3S
Molecular Weight	233.67 g/mol
Synonyms	5-Chloro-2-acetamidothiophene-3-carboxylic acid methyl ester; Methyl 5-chloro-2-acetamidothiophene-3-carboxylate; 2-Acetamido-5-chlorothiophene-3-carboxylic acid methyl ester; 3-Thiophenecarboxylic acid, 2-(acetylamino)-5-chloro-, methyl ester; 5-Chloro-2-acetylaminothiophene-3-carboxylic acid methyl ester; 2-Acetylamino-5-chlorothiophene-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 2-(Acetylamino)-5-Chloro-3-Thiophenecarboxylate is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.