Description

Bicyclo[1.1.1]Pentan-1-Ol is a highly strained, rigid bicyclic alcohol with a unique bridgehead structure, serving as a valuable and versatile building block in advanced organic synthesis. Its compact, three-dimensional geometry is critical for modulating the physicochemical properties of target molecules, offering significant advantages in drug discovery and materials science. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with enhanced metabolic stability, bioavailability, or specific material characteristics.

Application

• Pharmaceutical Intermediates: Key precursor for synthesizing bioisosteres, particularly as a rigid scaffold to replace phenyl or tert-butyl groups, improving drug-like properties.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where its unique spatial configuration can enhance target binding and environmental stability.
• Ligand and Catalyst Design: Employed as a backbone for creating sterically demanding, chiral ligands used in asymmetric catalysis.
• Polymer and Materials Science: Serves as a monomer or cross-linking agent for producing high-performance polymers with tailored rigidity and thermal properties.
• Chemical Biology Probes: Utilized to create molecular probes and tags that leverage its small, stable, and functionalizable structure for studying biological systems.
• Academic and R&D: Fundamental building block in methodological research for studying strain-release reactions and novel bond-forming transformations.

Basic Information

Product Name	Bicyclo[1.1.1]Pentan-1-Ol
CAS No.	22287-25-8
Molecular Formula	C5H8O
Molecular Weight	84.12 g/mol
Synonyms	1-Bicyclo[1.1.1]pentanol; [1.1.1]Propellanol; Pentaspirane-1-ol; Bridgehead Bicyclopentanol; BCP-OH; 1-Hydroxybicyclo[1.1.1]pentane; 1-BCP-ol; (1.1.1)Propellane-1-ol
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]Pentan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to guarantee consistent quality and traceability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.